BDBM613479 US11731943, Example 220::methyl N-[4-carbamoyl-1-[4- (cyanomethyl)-3-fluoro-1-[[4-(2- furyl)phenyl]methyl]-4- piperidyl]pyrazol-3-yl]carbamate

SMILES COC(=O)Nc1nn(cc1C(N)=O)C1(CC#N)CCN(Cc2ccc(cc2)-c2ccco2)CC1F

InChI Key InChIKey=VQEWGRQBHKVVPZ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613479   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613479(US11731943, Example 220 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.270nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613479(US11731943, Example 220 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.440nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent