BDBM613452 1-[4-(cyanomethyl)-3-fluoro-1- [(6-phenyl-3-pyridyl)methyl]-4- piperidyl]-3- (cyclopropanecarbonylamino) pyrazole-4-carboxamide::US11731943, Example 193

SMILES NC(=O)c1cn(nc1NC(=O)C1CC1)C1(CC#N)CCN(Cc2ccc(nc2)-c2ccccc2)CC1F

InChI Key InChIKey=AWQZJWWJRJMWDZ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613452   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613452(1-[4-(cyanomethyl)-3-fluoro-1- [(6-phenyl-3-pyridy...)
Affinity DataKi:  0.260nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613452(1-[4-(cyanomethyl)-3-fluoro-1- [(6-phenyl-3-pyridy...)
Affinity DataKi:  0.330nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent