BDBM612305 US11724992, Compound 102::US11724992, Example 6

SMILES CC(C)(c1ncc(s1)[S@@](=NC(=O)Nc2c3c(cc4c2CCC4)CCC3)(=O)N)O

InChI Key InChIKey=LHVWNNYPUDZLSH-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 612305   

LigandChemical structure of BindingDB Monomer ID 612305BDBM612305(US11724992, Example 6 | US11724992, Compound 102)
Affinity DataIC50: 24nMAssay Description:THP-1 cells were purchased from the American Type Culture Collection and sub-cultured according to instructions from the supplier. Prior to experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 612305BDBM612305(US11724992, Example 6 | US11724992, Compound 102)
Affinity DataIC50: 36nMAssay Description:Antagonist activity against NLRP3 in PMA-primed human THP-1 cells assessed as inhibition of gramicidin-induced IL-1beta release measured after 1 hr i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)