BDBM612298 (E)-N-(4-((4-([1,2,4]triazolo[1,5- c]pyrimidin-7-yloxy)-3- methylphenyl)amino)-5-(((R)-3,3- difluoro-1-methylpiperidin-4- yl)oxy)quinazolin-6-yl)-3-((R)-1- methylpyrrolidin-2-yl)acrylamide::US11723908, Example 95

SMILES CN1CCC[C@@H]1\C=C\C(=O)Nc1ccc2ncnc(Nc3ccc(Oc4cc5ncnn5cn4)c(C)c3)c2c1O[C@@H]1CCN(C)CC1(F)F

InChI Key InChIKey=LVUHOOHMDJWZHA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 612298   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM612298(US11723908, Example 95 | (E)-N-(4-((4-([1,2,4]tria...)
Affinity DataIC50: 48nMAssay Description:Inhibition of phosphor HER2 was determined by enzyme-linked immunosorbent assay (ELISA) in BT474 cells. BT474 cell line was purchased from ATCC (cata...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
Go to US Patent