BDBM612271 (S)-N-(4-([1,2,4]triazolo[1,5-c]pyrimidin-7-yloxy)-3-methylphenyl)-5-(7-fluoro-5-methyl-2,5-diazaspiro[3.4]octan-2-yl)-6-methoxyquinazolin-4-amine::US11723908, Example 44

SMILES COc1ccc2ncnc(Nc3ccc(Oc4cc5ncnn5cn4)c(C)c3)c2c1N1CC2(C1)C[C@@H](F)CN2C

InChI Key InChIKey=JRYLIHMRXPLXCQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 612271   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM612271(US11723908, Example 44 | (S)-N-(4-([1,2,4]triazolo...)
Affinity DataIC50: 5nMAssay Description:Inhibition of phosphor HER2 was determined by enzyme-linked immunosorbent assay (ELISA) in BT474 cells. BT474 cell line was purchased from ATCC (cata...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
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TargetEpidermal growth factor receptor(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM612271(US11723908, Example 44 | (S)-N-(4-([1,2,4]triazolo...)
Affinity DataIC50: 234nMAssay Description:Inhibition of phosphor wt-EGFR was determined by enzyme-linked immunosorbent assay (ELISA) in NCI H838 cells (ATCC, catalog number CRL-5844). Human P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
Go to US Patent