BDBM612264 (S)-N-(4-([1,2,4]-triazolo[1,5-c]pyrimidin-7-yloxy)-3-methylphenyl)-5-((3,3-difluoro-1-methylpiperidin-4-yl)oxy)-6-(methoxy-d3)quinazolin-4-amine::BDBM612287::US11723908, Example 37

SMILES COc1ccc2ncnc(Nc3ccc(Oc4cc5ncnn5cn4)c(C)c3)c2c1O[C@@H]1CCN(C)CC1(F)F

InChI Key InChIKey=PTKRHBXNNDLRPO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 612264   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM612264((S)-N-(4-([1,2,4]-triazolo[1,5-c]pyrimidin-7-yloxy...)
Affinity DataIC50: 12nMAssay Description:Inhibition of phosphor HER2 was determined by enzyme-linked immunosorbent assay (ELISA) in BT474 cells. BT474 cell line was purchased from ATCC (cata...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM612264((S)-N-(4-([1,2,4]-triazolo[1,5-c]pyrimidin-7-yloxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of phosphor wt-EGFR was determined by enzyme-linked immunosorbent assay (ELISA) in NCI H838 cells (ATCC, catalog number CRL-5844). Human P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM612264((S)-N-(4-([1,2,4]-triazolo[1,5-c]pyrimidin-7-yloxy...)
Affinity DataIC50: 14nMAssay Description:Inhibition of phosphor HER2 was determined by enzyme-linked immunosorbent assay (ELISA) in BT474 cells. BT474 cell line was purchased from ATCC (cata...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
Go to US Patent