BDBM612259 (S)-N-(4-([1,2,4]triazolo[1,5-c]pyrimidin-7-yloxy)-3-methylphenyl)-5-((3,3-difluoro-1-methylpiperidin-4-yl)oxy)-6-methoxyquinazolin-4-amine::US11723908, Example 32

SMILES COc1ccc2ncnc(Nc3ccc(Cc4cc5ncnn5cn4)c(C)c3)c2c1O[C@H]1CCN(C)CC1(F)F

InChI Key InChIKey=BPOIIGZUTDWCTR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 612259   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM612259(US11723908, Example 32 | (S)-N-(4-([1,2,4]triazolo...)
Affinity DataIC50: 16nMAssay Description:Inhibition of phosphor HER2 was determined by enzyme-linked immunosorbent assay (ELISA) in BT474 cells. BT474 cell line was purchased from ATCC (cata...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM612259(US11723908, Example 32 | (S)-N-(4-([1,2,4]triazolo...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of phosphor wt-EGFR was determined by enzyme-linked immunosorbent assay (ELISA) in NCI H838 cells (ATCC, catalog number CRL-5844). Human P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
Go to US Patent