BDBM611576 US11718603, Example 1::US20230321042, Compound C

SMILES CCCNC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccnc(OC)c2)n[nH]1

InChI Key InChIKey=VKZHSGOJYOUKNB-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 611576   

LigandPNGBDBM611576(US11718603, Example 1 | US20230321042, Compound C)
Affinity DataKi:  0.550nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

LigandPNGBDBM611576(US11718603, Example 1 | US20230321042, Compound C)
Affinity DataKi:  0.550nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM611576(US11718603, Example 1 | US20230321042, Compound C)
Affinity DataKi:  26.2nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
Go to US Patent

LigandPNGBDBM611576(US11718603, Example 1 | US20230321042, Compound C)
Affinity DataKi:  149nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

LigandPNGBDBM611576(US11718603, Example 1 | US20230321042, Compound C)
Affinity DataKi:  215nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent