BDBM610429 2-(5-Ethyl-3-methyl-[1,2,4]triazol-1-yl)-1-{(R)-2-hydroxymethyl-4-[2-trifluoromethyl-4-(2-trifluoromethyl-pyrimidin-5-yl)-thiazol-5-yl]-piperazin-1-yl}-ethanone::US10053457, Example 25

SMILES CCc1nc(C)nn1CC(=O)N1CCN(C[C@@H]1CO)c1sc(nc1-c1cnc(nc1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=MKFZBSCJKIDDTN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 610429   

TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM610429(US10053457, Example 25 | 2-(5-Ethyl-3-methyl-[1,2,...)
Affinity DataIC50: 3.60nMAssay Description:The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
Go to US Patent

TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM610429(US10053457, Example 25 | 2-(5-Ethyl-3-methyl-[1,2,...)
Affinity DataIC50: 664nMAssay Description:Stock solutions of test compounds are made up at a concentration of 10 mM in DMSO, and serially diluted in PBS containing 0.5% BSA to concentrations ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
Go to US Patent