BDBM609858 1-(4-chloro-3-fluorophenyl)-9-(5-((1R,2R)-2-(trifluoromethyl)cyclopropyl)-1,2,4-oxadiazol-3-yl)-1,9-diazaspiro[5.5]undecan-2-one, or 1-(4-chloro-3-fluorophenyl)-9-(5-((1S,2S)-2-(trifluoromethyl)cyclopropyl)-1,2,4-oxadiazol-3-yl)-1,9-diazaspiro[5.5]undecan-2-one and::US11708366, Example 6a

SMILES Fc1cc(ccc1Cl)N1C(=O)CCCC11CCN(CC1)c1noc(n1)[C@@H]1C[C@H]1C(F)(F)F

InChI Key InChIKey=GEHDYYRGGQVYBY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 609858   

TargetLeukotriene C4 synthase(Human)
Novartis

US Patent
LigandPNGBDBM609858(1-(4-chloro-3-fluorophenyl)-9-(5-((1R,2R)-2-(trifl...)
Affinity DataIC50: 1.90E+5nMAssay Description:LTC4 synthase catalyzes the conversion of Leukotriene A4(LTA4) to Leukotriene C4 (LTC4) in the presence of reduced glutathione (GSH) as a co-substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
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