BDBM60981 (2,3-diphenyl-1,2,4-thiadiazol-5-ylidene)-methyl-amine;hydrobromide::CHEMBL161867::MLS002153327::N-methyl-2,3-diphenyl-1,2,4-thiadiazol-5-imine;hydrobromide::SCH-202676 hydrobromide::SMR001230740::cid_11957689

SMILES C\N=c1/nc(-c2ccccc2)n(s1)-c1ccccc1

InChI Key InChIKey=FFUBTEITUNMMOK-UHFFFAOYSA-N

Data  12 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 60981   

TargetDNA dC->dU-editing enzyme APOBEC-3G(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 1.59E+4nMT: 2°CAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2011
Entry Details
PCBioAssay
TargetDNA dC->dU-editing enzyme APOBEC-3A(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 1.00E+5nMT: 2°CAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2011
Entry Details
PCBioAssay
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataEC50:  2.80E+3nMAssay Description:Effective concentration for displacement of [3H]-CCPA from human adenosine A1 receptor after 60 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 460nMAssay Description:Inhibition of full length His-NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as SAH production by Mtase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 193nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataKd:  798nMAssay Description:Binding affinity to CM5 chip-immobilised full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells assessed as d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 409nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 302nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 206nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 191nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 655nMAssay Description:Inhibition of SARS-CoV-2 PLpro using RLRGG-AMC substrate preincubated for 30 mins followed by substrate addition measured for 5 mins by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetChymotrypsinogen B2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of chymotrypsin (unknown origin) using N-succinyl-AAPF-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Cathepsin B using Z-RR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 10 mins by FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Cathepsin L using Z-VVR-AMC as substrate measured for 10 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed