BDBM608937 1-(6-{(4M)-4-(5-Chloro-6- methyl-1H-indazol-4-yl)-3-[2- (2-methoxyethyl)-2H-indazol- 5-yl]-5-methyl-1H-pyrazol-1- yl}-2-azaspiro[3.3]heptan-2- yl)prop-2-en-1-one::US11702409, Example 41a::US11702409, Example 41b

SMILES COCCn1cc2cc(ccc2n1)-c1nn(C2CC3(C2)CN(C3)C(=O)C=C)c(C)c1-c1c(Cl)c(C)cc2[nH]ncc12

InChI Key InChIKey=GVYWKAJMIXYEAW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 608937   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM608937(US11702409, Example 41a | US11702409, Example 41b ...)
Affinity DataIC50: 11nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM608937(US11702409, Example 41a | US11702409, Example 41b ...)
Affinity DataIC50: 941nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetGTPase KRas(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM608937(US11702409, Example 41a | US11702409, Example 41b ...)
Affinity DataIC50: 4nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed