BDBM608909 (3M)-6-[(6R)-6-amino-5,6- dihydrospiro[cyclopenta[b] pyridine-7,4'-piperidin]-1'- yl]-3-(2,3-dichlorophenyl)- 2,5-dimethyl-3,4- dihydropyrimidin-4-one::US11702392, Compound 75

SMILES Cc1nc(N2CCC3(CC2)[C@H](N)Cc2cccnc32)c(C)c(=O)n1-c1cccc(Cl)c1Cl

InChI Key InChIKey=URBIAZABDZPQER-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 608909   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM608909(US11702392, Compound 75 | (3M)-6-[(6R)-6-amino-5,6...)
Affinity DataIC50: 120nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent