BDBM608905 (3M)-6-[(1S)-1-amino-1,3- dihydrospiro[indene-2,4'- piperidin]-1'-yl]-3-(2,3- dichlorophenyl)-2,5-dimethyl-3,4- dihydropyrimidin-4-one::US11702392, Compound 74a

SMILES Cc1nc(N2CC[C@]3(Cc4ccccc4[C@H]3N)CC2)c(C)c(=O)n1-c1cccc(Cl)c1Cl

InChI Key InChIKey=MFHWVKLJXFEKJX-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 608905   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM608905(US11702392, Compound 74a | (3M)-6-[(1S)-1-amino-1,...)
Affinity DataIC50: 1nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM608905(US11702392, Compound 74a | (3M)-6-[(1S)-1-amino-1,...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of the ion channel hErg (or Kv11.1) current causes QT interval prolongation resulting in potentially fatal ventricular tachyarrhythmia cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent