BDBM608886 1-{6-[(4M)-4-(5-Chloro-6- methyl-1H-indazol-4-yl)-5- methyl-3-phenyl-1H-pyrazol- 1-yl]-2-azaspiro[3.3]heptan-2- yl}prop-2-en-1-one::US11702409, Example 26a::US11702409, Example 26b

SMILES Cc1c(c(nn1C1CC2(C1)CN(C2)C(=O)C=C)-c1ccccc1)-c1c(Cl)c(C)cc2[nH]ncc12

InChI Key InChIKey=NWYMNUYUDBBQTQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 608886   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM608886(US11702409, Example 26a | 1-{6-[(4M)-4-(5-Chloro-6...)
Affinity DataIC50: 43nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM608886(US11702409, Example 26a | 1-{6-[(4M)-4-(5-Chloro-6...)
Affinity DataIC50: 4.56E+4nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetGTPase KRas(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM608886(US11702409, Example 26a | 1-{6-[(4M)-4-(5-Chloro-6...)
Affinity DataIC50: 20nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed