BDBM608857 US11702409, Example 15a::US11702409, Example 15b

SMILES CN(C)CCn1ncc2cc(ccc12)-c1nn(C2CC3(C2)CN(C3)C(=O)C=C)c(C)c1-c1c(Cl)c(C)cc2[nH]ncc12

InChI Key InChIKey=OAQUOYUTTVTTQF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 608857   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM608857(US11702409, Example 15a | US11702409, Example 15b)
Affinity DataIC50: 16nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM608857(US11702409, Example 15a | US11702409, Example 15b)
Affinity DataIC50: 4.80E+3nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetGTPase KRas(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM608857(US11702409, Example 15a | US11702409, Example 15b)
Affinity DataIC50: 30nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed