BDBM608856 US11702409, Example 14

SMILES Cc1c(c(nn1C1CC2(C1)CN(C2)C(=O)C=C)-c1ccc2cn[nH]c2c1)-c1c(Cl)c(C)cc2[nH]ncc12

InChI Key InChIKey=AVMXYMIEZNSWPU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 608856   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM608856(US11702409, Example 14)
Affinity DataIC50: 310nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetGTPase KRas(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM608856(US11702409, Example 14)
Affinity DataIC50: 50nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed