BDBM608754 US11701354, Example 19::US11701354, Example 23

SMILES CN([C@H]1CCCC[C@@H]1N)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1F

InChI Key InChIKey=RFXWCCYVXQFKOC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 608754   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
D. E. Shaw Research

US Patent
LigandPNGBDBM608754(US11701354, Example 19 | US11701354, Example 23)
Affinity DataIC50: 1.00E+3nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
D. E. Shaw Research

US Patent
LigandPNGBDBM608754(US11701354, Example 19 | US11701354, Example 23)
Affinity DataIC50: 5.50E+3nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent