BDBM608520 (4M)-2-[(3S)-3-amino-3H-spiro[furo[2,3- b]pyridine-2,4'-piperidin]-1'-yl]-5-(2,3- dichlorophenyl)-6-methylpyrimidine-4- carboxamide::US11696916, Compound 125::US11696916, Compound 127

SMILES Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC2(CC1)Oc1ncccc1[C@@H]2N

InChI Key InChIKey=OVHDDZFBOAHCAC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 608520   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM608520(US11696916, Compound 125 | (4M)-2-[(3S)-3-amino-3H...)
Affinity DataIC50: 530nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM608520(US11696916, Compound 125 | (4M)-2-[(3S)-3-amino-3H...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent