BDBM608516 6-amino-2-[(4S)-4-amino-4,6- dihydrospiro[cyclopenta[d][1,3]thiazole- 5,4'-piperidin]-1'-yl]-5-(2,3- dichlorophenyl)pyrimidine-4- carboxamide::US11696916, Compound 121

SMILES Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC2(Cc3scnc3[C@H]2N)CC1

InChI Key InChIKey=GGBPZIQYTKFOGP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 608516   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM608516(US11696916, Compound 121 | 6-amino-2-[(4S)-4-amino...)
Affinity DataIC50: 2nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
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