BDBM608371 (Z)-15-chloro-21-(2-methoxyethyl)-13,23,61- trimethyl-11H,21H,61H-10-oxa-4,8-dithia- 1(4,1)-indola-2(4,5),6(3,5)-dipyrazola-9(3,1)- naphthalenacyclotridecaphane-12-carboxylic acid::US11691989, Compound 27

SMILES COCCn1nc(C)c-2c1CSCc1cc(CSc3cc(OCCCn4c(C(O)=O)c(C)c5c-2c(Cl)ccc45)c2ccccc2c3)n(C)n1

InChI Key InChIKey=NBKBYJXHMITPQK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 608371   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-323](Human)
Ascentage Pharma (Suzhou)

US Patent
LigandPNGBDBM608371(US11691989, Compound 27 | (Z)-15-chloro-21-(2-meth...)
Affinity DataIC50: 15nMAssay Description:The relative binding potency of representative Compounds of the Disclosure was determined by a fluorescence polarization (FP) assay. The method used ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent