BDBM608346 (Z)-15-chloro-96-fluoro-13,61-dimethyl-26,27- dihydro-11H,24H,61H-10-oxa-4,8-dithia- 2(3,2)-pyrazolo[5,1-c][1,4]oxazina-1(4,1)- indola-6(3,5)-pyrazola-9(3,1)- naphthalenacyclotridecaphane-12-carboxylic acid::US11691989, Compound 4

SMILES Cc1c(C(O)=O)n2CCCOc3cc(SCc4cc(CSCc5nn6CCOCc6c5-c5c(Cl)ccc2c15)nn4C)cc1cc(F)ccc31

InChI Key InChIKey=MBTBSGBPYIAEHM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 608346   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-323](Human)
Ascentage Pharma (Suzhou)

US Patent
LigandPNGBDBM608346(US11691989, Compound 4 | (Z)-15-chloro-96-fluoro-1...)
Affinity DataIC50: 14nMAssay Description:The relative binding potency of representative Compounds of the Disclosure was determined by a fluorescence polarization (FP) assay. The method used ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent