BDBM608220 US11691971, Example 12

SMILES CSc1c(Nc2cc(NC(=O)C3CC3)nc3cc[nH]c(=O)c23)cccc1-c1cnn(c1)C1CCOCC1

InChI Key InChIKey=CRFAWDQACBXOLK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 608220   

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM608220(US11691971, Example 12)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
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LigandPNGBDBM608220(US11691971, Example 12)
Affinity DataIC50: 750nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [V617F](Human)
Incyte

US Patent
LigandPNGBDBM608220(US11691971, Example 12)
Affinity DataIC50: 750nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent