BDBM605724 1-N'-[6-(6-carbamoyl-7- methoxyquinolin-4-yl)oxypyridin- 3-yl]-1-N-(4- fluorophenyl)cyclopropane-1,1- dicarboxamide::US11673897, Compound 16

SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cn3)c2cc1C(N)=O

InChI Key InChIKey=DWWVYRLEAFDFDV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605724   

LigandPNGBDBM605724(US11673897, Compound 16 | 1-N'-[6-(6-carbamoyl-7- ...)
Affinity DataIC50: 55nMAssay Description:Human Axl (residues H473-A894 with Q764R, 161 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG (SEQ ID NO. 43), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
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LigandPNGBDBM605724(US11673897, Compound 16 | 1-N'-[6-(6-carbamoyl-7- ...)
Affinity DataIC50: 10nMAssay Description:Human Mer (residues R557-E882 with H628Q and R794A, 0.7 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl, 250 μM GGMEDIYFEFMGGKK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

LigandPNGBDBM605724(US11673897, Compound 16 | 1-N'-[6-(6-carbamoyl-7- ...)
Affinity DataIC50: 10nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent