BDBM605541 (1S,3R)-N-(5-chloro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro- 1H-benzo[d]pyrrolo[1,2-a]imidazol-7- yl)pyridin-2-yl)-3-propionamidocyclohexane-1-carboxamide::US11673893, Example 17

SMILES CCC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nc3CCC(C)(C)n3c2c1

InChI Key InChIKey=VGKOYNIMZVZLAN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605541   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM605541(US11673893, Example 17 | (1S,3R)-N-(5-chloro-4-(5-...)
Affinity DataIC50: 2.31nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK4/Cyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM605541(US11673893, Example 17 | (1S,3R)-N-(5-chloro-4-(5-...)
Affinity DataIC50: 80.2nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK2/Cyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM605541(US11673893, Example 17 | (1S,3R)-N-(5-chloro-4-(5-...)
Affinity DataIC50: 297nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK9/Cyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent