BDBM605453 6-(2-aminopyrimidin-5-yl)-N-(1-(4- fluorophenyl)ethyl)quinazolin-4-amine::US11673876, Compound 121

SMILES CC(Nc1ncnc2ccc(cc12)-c1cnc(N)nc1)c1ccc(F)cc1

InChI Key InChIKey=XNMPSWKRCXDQGI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605453   

LigandPNGBDBM605453(6-(2-aminopyrimidin-5-yl)-N-(1-(4- fluorophenyl)et...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandPNGBDBM605453(6-(2-aminopyrimidin-5-yl)-N-(1-(4- fluorophenyl)et...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandPNGBDBM605453(6-(2-aminopyrimidin-5-yl)-N-(1-(4- fluorophenyl)et...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
Go to US Patent