BDBM605450 N-(2-chloro-5-(3-cyano-4-((1-(4- fluorophenyl)ethyl)amino)quinolin-6- yl)pyridin-3-yl)methanesulfonamide::US11673876, Compound 97

SMILES CC(Nc1c(cnc2ccc(cc12)-c1cnc(Cl)c(NS(C)(=O)=O)c1)C#N)c1ccc(F)cc1

InChI Key InChIKey=ZOELGAFLBORUDS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605450   

LigandPNGBDBM605450(N-(2-chloro-5-(3-cyano-4-((1-(4- fluorophenyl)ethy...)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
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TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandPNGBDBM605450(N-(2-chloro-5-(3-cyano-4-((1-(4- fluorophenyl)ethy...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandPNGBDBM605450(N-(2-chloro-5-(3-cyano-4-((1-(4- fluorophenyl)ethy...)
Affinity DataIC50: 2nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
Go to US Patent