BDBM605441 6-(5,6-dimethoxypyridin-3-yl)-N-(1- phenylethyl)quinazolin-4-amine::US11673876, Compound 22

SMILES COc1cc(cnc1OC)-c1ccc2ncnc(NC(C)c3ccccc3)c2c1

InChI Key InChIKey=ZLKQIOPKHPXAFO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605441   

LigandPNGBDBM605441(6-(5,6-dimethoxypyridin-3-yl)-N-(1- phenylethyl)qu...)
Affinity DataIC50: 110nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
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TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandPNGBDBM605441(6-(5,6-dimethoxypyridin-3-yl)-N-(1- phenylethyl)qu...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandPNGBDBM605441(6-(5,6-dimethoxypyridin-3-yl)-N-(1- phenylethyl)qu...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
Go to US Patent