BDBM6050 3-[3-(2,5-dimethylthiophen-3-yl)-4-oxo-2H,4H-indeno[1,2-c]pyrazol-5-yl]-1-(4-methylpiperazin-1-yl)urea::C3 heterocyle indenopyrazole 8p

SMILES CN1CCN(CC1)NC(=O)Nc1cccc2-c3n[nH]c(-c4cc(C)sc4C)c3C(=O)c12

InChI Key InChIKey=OVOCLWYGFNGBTQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6050   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandPNGBDBM6050(3-[3-(2,5-dimethylthiophen-3-yl)-4-oxo-2H,4H-inden...)
Affinity DataIC50: 90nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandPNGBDBM6050(3-[3-(2,5-dimethylthiophen-3-yl)-4-oxo-2H,4H-inden...)
Affinity DataIC50: 12nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed