BDBM604842 Synthesis of 7-[(5R,7R,8R,12aR,14R,15R,15aR,16R)-14-(6-amino-9H-purin-9-yl)-15-fluoro-2,10,16-trihydroxy-2,10-dioxidooctahydro-12H-5,8-methanofuro[3,2-1][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecin-7-yl]-5-fluoro-3-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one di-triethylamine salt::US11666594, Example 25::US12171777, Example 25

SMILES Cn1cnc2n(cc(F)c2c1=O)[C@@H]1O[C@@H]2COP(O)(=O)O[C@@H]3[C@@H](COP(O)(=O)O[C@@H]1[C@@H]2O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12

InChI Key InChIKey=IPXQHNRSBUKHFP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 604842   

TargetStimulator of interferon genes protein(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM604842(Synthesis of 7-[(5R,7R,8R,12aR,14R,15R,15aR,16R)-1...)
Affinity DataIC50: 83nMAssay Description:The above-mentioned biotinylated STING protein (wild-type (WT)) was prepared by the following method. The culture solution was centrifuged, the obtai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
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TargetStimulator of interferon genes protein(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM604842(Synthesis of 7-[(5R,7R,8R,12aR,14R,15R,15aR,16R)-1...)
Affinity DataIC50: 83nMAssay Description:Test compound (2 μL), Streptavidin-Terbium (4 μL, Cisbio), Fluorescein-labeled 2′,3′-cGAMP (c[G(2′,5′)p-2′-Fluo-AHC-A(3′,5′)p]) (Biolog, Germany) and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2025
Entry Details
Go to US Patent