BDBM604319 4-(9-Cyclopropyl-4- methyl-8-(4-((4- (methylsulfonyl)piperidin- 1-yl)methyl)phenyl)-3- oxo-1,3,4,7-tetrahydro-::US11661422, Example 23

SMILES CN1C(=O)N(Cc2c1cnc1[nH]c(c(C3CC3)c21)-c1ccc(CN2CCC(CC2)S(C)(=O)=O)cc1)c1ccc(cc1)C(O)=O

InChI Key InChIKey=FGZXICKVUKFIPY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 604319   

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM604319(US11661422, Example 23 | 4-(9-Cyclopropyl-4- methy...)
Affinity DataIC50: 2.50E+3nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
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Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604319(US11661422, Example 23 | 4-(9-Cyclopropyl-4- methy...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604319(US11661422, Example 23 | 4-(9-Cyclopropyl-4- methy...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandPNGBDBM604319(US11661422, Example 23 | 4-(9-Cyclopropyl-4- methy...)
Affinity DataIC50: 2.50E+3nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent