BDBM604314 9-(4-(4-Acetylpiperazin- 1-yl)phenyl)-2-(tert- butyl)-4-methyl-8-(4-((4- (methylsulfonyl)piperidin- 1-yl)methyl)phenyl)- 1,2,4,7-tetrahydro-3H- pyrrolo[3',2':5,6]pyrido[3, 4-d]pyrimidin-3-one, trifluoroacetic acid salt::US11661422, Example 18
SMILES CN1C(=O)N(Cc2c1cnc1[nH]c(c(-c3ccc(cc3)N3CCN(CC3)C(C)=O)c21)-c1ccc(CN2CCC(CC2)S(C)(=O)=O)cc1)C(C)(C)C
InChI Key InChIKey=FIBPJTGKYDUBSN-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 604314
Affinity DataIC50: 100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair