BDBM604221 (4R)-N-[2,3-dimethoxy-6H,7H,8H- cyclopenta[b]1,5-naphthyridin-9-yl] azepan-4-amine::US11661410, No. 163::US11661410, No. 165

SMILES COc1cc2nc3CCCc3c(N[C@@H]3CCCN(C)CC3)c2nc1OC

InChI Key InChIKey=WMSNDYIAXSZUFY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 604221   

TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604221(US11661410, No. 163 | (4R)-N-[2,3-dimethoxy-6H,7H,...)
Affinity DataIC50: 158nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604221(US11661410, No. 163 | (4R)-N-[2,3-dimethoxy-6H,7H,...)
Affinity DataIC50: 100nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent