BDBM604195 (3R)—N-{6,7-dimethoxy-1H,2H,3H-cyclopenta[b]quinolin-9-yl}-5,5-difluoropiperidin-3-amine::US11661410, No. 46::US11661410, No. 47

SMILES COc1cc2nc3ccccc3c(NC3CCN(CC3)C(C)C)c2cc1OC

InChI Key InChIKey=ULICVDNCMPOXNX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 604195   

TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604195(US11661410, No. 46 | US11661410, No. 47 | (3R)...)
Affinity DataIC50: 178nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604195(US11661410, No. 46 | US11661410, No. 47 | (3R)...)
Affinity DataIC50: 79.4nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent