BDBM604071 US11660293, Example 181::US11660293, Example 183

SMILES C[C@@H]1C2CC(C2)N(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1

InChI Key InChIKey=RTDCZMCDRZTDKL-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 604071   

TargetOrexin/Hypocretin receptor type 1(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM604071(US11660293, Example 181 | US11660293, Example 183)
Affinity DataKi:  4.90nMAssay Description:CHO cells stably transfected with human Orexin type 1 receptors (CHO-hOX1) or HEK-293 cells transiently transfected with human Orexin type 2 receptor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM604071(US11660293, Example 181 | US11660293, Example 183)
Affinity DataKi:  8.13nMAssay Description:CHO cells stably transfected with human Orexin type 1 receptors (CHO-hOX1) or HEK-293 cells transiently transfected with human Orexin type 2 receptor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM604071(US11660293, Example 181 | US11660293, Example 183)
Affinity DataKi:  5.50E+3nMAssay Description:CHO cells stably transfected with human Orexin type 1 receptors (CHO-hOX1) or HEK-293 cells transiently transfected with human Orexin type 2 receptor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM604071(US11660293, Example 181 | US11660293, Example 183)
Affinity DataKi:  8.13E+3nMAssay Description:CHO cells stably transfected with human Orexin type 1 receptors (CHO-hOX1) or HEK-293 cells transiently transfected with human Orexin type 2 receptor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent