BDBM602728 2-[1-(2-Isoindolin-2-yl-6-methyl-4-oxo-chromen-8-yl)ethylamino]benzoic acid::US11649227, Example 363

SMILES C[C@H](Nc1ccccc1C(O)=O)c1cc(C)cc2c1oc(cc2=O)N1Cc2ccccc2C1

InChI Key InChIKey=ZRSCVKQQFCOUGY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 602728   

LigandPNGBDBM602728(US11649227, Example 363 | 2-[1-(2-Isoindolin-2-yl-...)
Affinity DataIC50: 110nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

LigandPNGBDBM602728(US11649227, Example 363 | 2-[1-(2-Isoindolin-2-yl-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

LigandPNGBDBM602728(US11649227, Example 363 | 2-[1-(2-Isoindolin-2-yl-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

LigandPNGBDBM602728(US11649227, Example 363 | 2-[1-(2-Isoindolin-2-yl-...)
Affinity DataIC50: 450nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Petra Pharma

US Patent
LigandPNGBDBM602728(US11649227, Example 363 | 2-[1-(2-Isoindolin-2-yl-...)
Affinity DataIC50: 980nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Petra Pharma

US Patent
LigandPNGBDBM602728(US11649227, Example 363 | 2-[1-(2-Isoindolin-2-yl-...)
Affinity DataIC50: 7.80E+3nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent