BDBM602718 US11649227, Example 376::US20230286960, Example 376*

SMILES C[C@@H](Nc1ccccc1C(O)=O)c1cc(C)cc2c1oc(cc2=O)N1CCCCC1

InChI Key InChIKey=AMPHAZIYGFLWJC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 602718   

LigandPNGBDBM602718(US11649227, Example 376 | US20230286960, Example 3...)
Affinity DataIC50: 3.00E+3nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

LigandPNGBDBM602718(US11649227, Example 376 | US20230286960, Example 3...)
Affinity DataIC50: 500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

LigandPNGBDBM602718(US11649227, Example 376 | US20230286960, Example 3...)
Affinity DataIC50: 3.00E+3nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

LigandPNGBDBM602718(US11649227, Example 376 | US20230286960, Example 3...)
Affinity DataIC50: 500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

LigandPNGBDBM602718(US11649227, Example 376 | US20230286960, Example 3...)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant N-terminal 6-His tagged full length human PI3Kalpha H1047R mutant using PIP2diC8 and PIP2:PS as substrate incubated for 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed