BDBM602218 (R)-4-(4-((1-(3-(difluoromethyl)-2- fluorophenyl)ethyl)amino)-7-methoxy-2- methylpyrido[2,3-d]pyrimidin-6- yl)tetrahydro-2H- thiopyran-4-carbonitrile 1,1-dioxide::US11648254, Compound 126

SMILES COc1nc2nc(C)nc(N[C@H](C)c3cccc(C(F)F)c3F)c2cc1C1(CCS(=O)(=O)CC1)C#N

InChI Key InChIKey=JGXYMPJLKYYTNM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 602218   

TargetSon of sevenless homolog 1(Human)
Kumquat Biosciences

US Patent
LigandPNGBDBM602218(US11648254, Compound 126 | (R)-4-(4-((1-(3-(difluo...)
Affinity DataIC50: 100nMAssay Description:The ability of any compound of the present disclosure to reduce a Ras protein signaling output by, e.g., interfering or disrupting interaction (or bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent