BDBM601961 7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 74::US20240150369, Compound 74

SMILES O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1

InChI Key InChIKey=CEIJSVLEARLWRF-UHFFFAOYSA-N

Data  18 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 601961   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 8nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/9/2024
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TargetCDK2/Cyclin-E2(Human)
Pharmacosmos Holding

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 8nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Date in BDB:
12/9/2025
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 8nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
6/11/2023
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TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 29nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
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TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 29nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
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TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 29nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
12/9/2025
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 60nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 60nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
12/9/2025
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 60nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
6/11/2023
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TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 92nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
Entry Details
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TargetCyclin-dependent kinase 5(Human)
Pharmacosmos Holding

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 92nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
12/9/2025
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TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 92nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
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Targetcdk3cyclin-e(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 106nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
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Targetcdk3cyclin-e(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 106nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/9/2025
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Targetcdk3cyclin-e(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 106nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Date in BDB:
6/11/2023
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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 137nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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In Depth
Date in BDB:
8/9/2024
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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 137nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Date in BDB:
12/9/2025
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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 137nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Date in BDB:
6/11/2023
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TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 258nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
Entry Details
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TargetCyclin-dependent kinase 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 258nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
Entry Details
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TargetCyclin-dependent kinase 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 258nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/9/2025
Entry Details
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Pharmacosmos Holding

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 653nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/9/2025
Entry Details
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Pharmacosmos Holding

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 653nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
6/11/2023
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Pharmacosmos Holding

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 653nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
8/9/2024
Entry Details
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TargetCyclin-H/Cyclin-dependent kinase 7(Human)
G1 Therapeutics

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/9/2024
Entry Details
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TargetCyclin-dependent kinase 7(Human)
Pharmacosmos Holding

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/9/2025
Entry Details
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TargetCyclin-dependent kinase 7(Human)
Pharmacosmos Holding

US Patent

LigandBDBM601961(US11643416, Compound 74 | 7'-((4-(morpholine-4- ca...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
Entry Details
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