BDBM601692 US11639355, Example 12-I

SMILES COc1ncc(-c2nc3C(=O)N([C@H](c3n2C(C)C)c2ccc(Cl)cc2)c2cc3OCOc3c(C)c2)c(OC)n1

InChI Key InChIKey=ACLLXTVQPKMSMX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 601692   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Luoxin Pharmaceutical (Shanghai)

US Patent
LigandPNGBDBM601692(US11639355, Example 12-I)
Affinity DataIC50: 0.690nMAssay Description:In the present disclosure, the enzyme level activity the compounds is detected by using the MDM2/p53 protein binding experiment and using a TR-FRET m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent