BDBM600014 5-{4-amino-5-[(4,4-difluoropiperidin-1- yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}- N-[(3R,4S)-1-(4-chloropyridine-3- carbonyl)-4-fluoropyrrolidin-3-yl]-2- methoxypyridine-3-carboxamide::US11618753, Example 1252

SMILES COc1ncc(cc1C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)c1cnccc1Cl)-c1cc(CN2CCC(F)(F)CC2)c2c(N)ncnn12

InChI Key InChIKey=HNLCXWFJPQAKJJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 600014   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM600014(US11618753, Example 1252 | 5-{4-amino-5-[(4,4-difl...)
Affinity DataIC50: 2.00E+3nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2023
Entry Details
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