BDBM599844 5-[4-amino-5- (trifluoromethyl)pyrrolo[2,1- f][1,2,4]triazin-7-yl]-2- (difluoromethoxy)-N-[(3R,4S)-4- fluoro-1-[(2R)-3,3,3-trifluoro-2- hydroxy-2- methylpropanoyl]pyrrolidin-3- yl]benzamide::US11618753, Example 1080

SMILES C[C@@](O)(C(=O)N1C[C@H](F)[C@@H](C1)NC(=O)c1cc(ccc1OC(F)F)-c1cc(c2c(N)ncnn12)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=GHHMZEBIZBTTQW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 599844   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM599844(US11618753, Example 1080 | 5-[4-amino-5- (trifluor...)
Affinity DataIC50: 1.60E+3nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2023
Entry Details
Go to US Patent