BDBM599472 5-[4-amino-5- (trifluoromethyl)pyrrolo[2,1- f][1,2,4]triazin-7-yl]-2-chloro-3- fluoro-N-[(3R,4S)-4-fluoro-1- (3,3,3-trifluoro-2- methylpropanoyl)pyrrolidin-3- yl]benzamide::US11618753, Example 1328::US11618753, Example 1329::US11618753, Example 633

SMILES CC(C(=O)N1C[C@H](F)[C@@H](C1)NC(=O)c1cc(cc(F)c1Cl)-c1cc(c2c(N)ncnn12)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=NDJMEHRBAVETTG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 599472   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM599472(5-[4-amino-5- (trifluoromethyl)pyrrolo[2,1- f][1,2...)
Affinity DataIC50: 8.20E+4nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2023
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM599472(5-[4-amino-5- (trifluoromethyl)pyrrolo[2,1- f][1,2...)
Affinity DataIC50: 1.60E+3nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2023
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM599472(5-[4-amino-5- (trifluoromethyl)pyrrolo[2,1- f][1,2...)
Affinity DataIC50: 1.20E+4nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2023
Entry Details
Go to US Patent