BDBM598664 Ethyl 2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluoro-N4-(1H-indazol-5-yl)-N6,N6-dimethylpyrimidine-4,6-diamine::US11613531, Example 342

SMILES CN(C)c1nc(nc(Nc2ccc3[nH]ncc3c2)c1F)N1C2CCC1CNC2

InChI Key InChIKey=YRJCLRKUABEIAN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 598664   

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598664(US11613531, Example 342 | Ethyl 2-(3,8-diazabicycl...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
Go to US Patent