BDBM598637 N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-cyclopropylpyrimidin-4-yl)-1H-indazol-5-amine::US11613531, Example 308

SMILES C1CC1c1cnc(nc1Nc1ccc2[nH]ncc2c1)N1C2CC1CNC2

InChI Key InChIKey=WSKXBQUGUZJGBN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 598637   

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598637(US11613531, Example 308 | N-(2-(3,6-diazabicyclo[3...)
Affinity DataIC50: 15nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
Go to US Patent