BDBM598493 3-(difluoromethyl)-N-{[2-fluoro-3-methoxy-6-(4-methyl-1,2,3-triazol-1- yl)phenyl]methyl}-1-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-3- yl)methyl]pyrazole-4-carboxamide::US11613527, Example 137

SMILES COc1ccc(c(CNC(=O)c2cn(Cc3cnc4CN(C)CCc4c3)nc2C(F)F)c1F)-n1cc(C)nn1

InChI Key InChIKey=JAEGJBCKXFFKGJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 598493   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598493(US11613527, Example 137 | 3-(difluoromethyl)-N-{[2...)
Affinity DataIC50: 10nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598493(US11613527, Example 137 | 3-(difluoromethyl)-N-{[2...)
Affinity DataIC50: 2.19E+4nMAssay Description:FXIa inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598493(US11613527, Example 137 | 3-(difluoromethyl)-N-{[2...)
Affinity DataIC50: 4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent