BDBM598464 1-[(4,4-difluoro-2-methyl-1,3-dihydroisoquinolin-6-yl)methyl]-N-{[2-fluoro-3- methoxy-6-(4-methyl-1,2,3-triazol-1-yl)phenyl]methyl}-3-(methoxymethyl)pyrazole- 4-carboxamide::US11613527, Example 105

SMILES COCc1nn(Cc2ccc3CN(C)CC(F)(F)c3c2)cc1C(=O)NCc1c(F)c(OC)ccc1-n1cc(C)nn1

InChI Key InChIKey=ZDKJNWKQAAGNGE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 598464   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598464(US11613527, Example 105 | 1-[(4,4-difluoro-2-methy...)
Affinity DataIC50: 10nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
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TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598464(US11613527, Example 105 | 1-[(4,4-difluoro-2-methy...)
Affinity DataIC50: 4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
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TargetCoagulation factor XI(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598464(US11613527, Example 105 | 1-[(4,4-difluoro-2-methy...)
Affinity DataIC50: 3.00E+4nMAssay Description:FXIa inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
Go to US Patent