BDBM598460 3-(difluoromethyl)-N-(2-fluoro-3-methoxy-6-(4-methyl-1H-1,2,3-triazol-1-yl)benzyl)- 1-((5'-methyl-5',6'-dihydro-4'H-spiro[cyclopropane-1,7'-pyrazolo[1,5-a]pyrazin]-2'- yl)methyl)-1H-pyrazole-4-carboxamide::US11613527, Example 82

SMILES COc1ccc(c(CNC(=O)c2cn(Cc3cc4CN(C)CC5(CC5)n4n3)nc2C(F)F)c1F)-n1cc(C)nn1

InChI Key InChIKey=UHCQEUIVWUTLRZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 598460   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598460(US11613527, Example 82 | 3-(difluoromethyl)-N-(2-f...)
Affinity DataIC50: 10nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
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TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598460(US11613527, Example 82 | 3-(difluoromethyl)-N-(2-f...)
Affinity DataIC50: 4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
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TargetCoagulation factor XI(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598460(US11613527, Example 82 | 3-(difluoromethyl)-N-(2-f...)
Affinity DataIC50: 1.82E+4nMAssay Description:FXIa inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
Go to US Patent