BDBM598454 N-({2-fluoro-3-methoxy-6-[3-(trifluoromethyl)-1,2,4-triazol-1-yl]phenyl}methyl)-1- [(2-isopropyl-1,3-dihydroisoindol-5-yl)methyl]-3-(methoxymethyl)pyrazole-4- carboxamide::US11613527, Example 60

SMILES COCc1nn(Cc2ccc3CN(Cc3c2)C(C)C)cc1C(=O)NCc1c(F)c(OC)ccc1-n1cnc(n1)C(F)(F)F

InChI Key InChIKey=NBLCMZKABACNAG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 598454   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598454(US11613527, Example 60 | N-({2-fluoro-3-methoxy-6-...)
Affinity DataIC50: 10nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
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Date in BDB:
5/9/2023
Entry Details
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TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598454(US11613527, Example 60 | N-({2-fluoro-3-methoxy-6-...)
Affinity DataIC50: 4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
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Date in BDB:
5/9/2023
Entry Details
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TargetCoagulation factor XI(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598454(US11613527, Example 60 | N-({2-fluoro-3-methoxy-6-...)
Affinity DataIC50: 4.00E+4nMAssay Description:FXIa inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
Go to US Patent