BDBM598423 N-{[6-(3-cyanopyrazol-1-yl)-2-fluoro-3-methoxyphenyl]methyl}-1-[(2-ethyl-3,4- dihydro-1H-isoquinolin-7-yl)methyl]-3-(methoxymethyl)pyrazole-4-carboxamide::US11613527, Example 27

SMILES CCN1CCc2ccc(Cn3cc(C(=O)NCc4c(F)c(OC)ccc4-n4ccc(n4)C#N)c(COC)n3)cc2C1

InChI Key InChIKey=DUGJECXUZZTYAR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 598423   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598423(US11613527, Example 27 | N-{[6-(3-cyanopyrazol-1-y...)
Affinity DataIC50: 10nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
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TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598423(US11613527, Example 27 | N-{[6-(3-cyanopyrazol-1-y...)
Affinity DataIC50: 4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
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TargetCoagulation factor XI(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM598423(US11613527, Example 27 | N-{[6-(3-cyanopyrazol-1-y...)
Affinity DataIC50: 3.39E+4nMAssay Description:FXIa inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
Go to US Patent